The safety and effectiveness of this drug hasn’t been established hinein children. It shouldn’t be used rein children younger than 18 years.

Methadone should be given with caution and the initial dose reduced rein certain patients, such as the elderly and debilitated and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease, prostatic hypertrophy, or urethral stricture.

Methadone hydrochloride tablets can cause physical dependence. Do not stop taking methadone hydrochloride tablets or any other opioid without first talking to your doctor. You could become sick with uncomfortable withdrawal symptoms because your body has become used to these medicines.

Methadone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Methadone hydrochloride tablets are a federally controlled substance (CII) because it is a strong opioid pain medicine that can be abused by people World health organization abuse prescription medicines or street drugs.

Overdose rein children warning: Children Weltgesundheitsorganisation accidentally take this drug have a high risk of death from overdosing. Children should not take this drug.

Fertility – Reproductive function hinein human males may Beryllium decreased by methadone treatment. Reductions hinein ejaculate volume and seminal vesicle and prostate secretions have been reported hinein methadone-treated individuals. Rein addition, reductions in serum testosterone levels and sperm motility, and abnormalities in Methadontabletten 10 mg online sperm morphology have been reported. Published animal studies provide additional data indicating that methadone treatment of males can lebensalter reproductive function.

Based on an average milk consumption of 150 mL/kg/day, an infant would consume approximately 17.4 mcg/kg/day which is approximately 2 to 3% of the oral maternal dose. Methadone has been detected in very low plasma concentrations hinein some infants whose mothers were taking methadone. Women on high-dose methadone maintenance, Weltgesundheitsorganisation are already breast-feeding, should Beryllium counseled to wean breast-feeding gradually hinein order to prevent neonatal abstinence syndrome.

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Sowie es durch den Opioidmissbrauch bereits nach einem sehr starken Sauerstoffmangel im Körper des Patienten gekommen sein sollte, können aus diesem Beweisgrund die Pupillen sogar bereits sehr stark erweitert sein, da es dann schon nach einer Opioid-Vergiftung gekommen ist.

Methadone products when used for the treatment of opioid addiction hinein detoxification or maintenance programs, shall be dispensed only by opioid treatment programs (and agencies, practitioners or institutions by formal agreement with the program sponsor) certified by the Substance Abuse and Mental Health Services Administration and approved by the designated state authority.

A high degree of "opioid tolerance" does not eliminate the possibility of methadone overdose, iatrogenic or otherwise. Respiratory depression is of particular concern rein elderly or debilitated patients as well as hinein those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.

Do not drink alcohol while using methadone hydrochloride tablets. It may increase the chance of having dangerous side effects.

Laboratory studies, both in vivo and rein vitro, have demonstrated that methadone inhibits cardiac potassium channels and prolongs the QT interval. Cases of QT interval prolongation and serious arrhythmia (torsades de pointes) have been observed during treatment with methadone. These cases appear to Beryllium more commonly associated with, but not limited to, higher dose treatment (> 200 mg/day). Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported rein patients receiving doses commonly used for maintenance treatment of opioid addiction.