Mutagenesis – There are several published reports on the potential genetic toxicity of methadone. Methadone tested negative hinein tests for chromosome breakage and disjunction and sex-linked recessive lethal gene mutations hinein germ cells of Drosophila using feeding and injection procedures.

Regardless of the dose determination strategy employed, methadone is most safely initiated and titrated using small initial doses and gradual dose adjustments.

Since the metabolism of methadone is mediated primarily by CYP3A4 isozyme, coadministration of drugs that inhibit CYP3A4 activity may cause decreased clearance of methadone. The expected clinical results would be increased or prolonged opioid effects. Thus, methadone-treated patients coadministered strong inhibitors of CYP3A4, such as azole antifungal agents (e.

Keep methadone hydrochloride tablets rein a safe place away from children. Accidental use by a child is a medical emergency that can result rein death.

Talk to your doctor about slowly stopping methadone hydrochloride tablets to avoid getting sick with withdrawal symptoms. Physical dependency is not the same as drug addiction.

It may harm them and even cause death. Selling or giving away this medicine is dangerous and against the law.

If you have a paralytic ileus (lack of muscle tone in the intestines that can cause GI obstructions), you shouldn’t take this drug.

Hepatic Impairment – Methadone has not been extensively evaluated rein patients with hepatic insufficiency. Methadone is metabolized by hepatic pathways, therefore patients with liver impairment may be at risk of accumulating methadone after multiple dosing.

Hinein most of the cases seen at typical maintenance doses, concomitant medications and/or clinical conditions such as hypokalemia were noted as contributing factors. Methadontabletten online kaufen However, the evidence strongly suggests that methadone possesses the potential for adverse cardiac conduction effects hinein some patients.

Methadone hydrochloride tablets can cause your blood pressure to drop. This can make you feel dizzy if you get up too fast from sitting or lying down.

In these patients, even usual therapeutic doses of methadone may decrease respiratory drive while simultaneously increasing airway resistance to the point of apnea. Alternative, non-opioid analgesics should Beryllium considered, and methadone should Beryllium used at the lowest effective dose and only under careful medical supervision.

For people with a head injury: This drug may cause increased pressure hinein your brain. This can raise your risk of complications or cause death.

If you’ve had a recent head injury, it increases your risk of breathing problems from methadone. Talk to your doctor about whether this drug is safe for you.

Narcotics with mixed agonist-antagonist properties should not Beryllium used for pain control during labor hinein patients chronically treated with methadone as they may precipitate acute withdrawal.