Methadone is contraindicated rein patients with a known hypersensitivity to methadone hydrochloride or any other ingredient rein methadone hydrochloride tablets.

Published animal data have reported increased neonatal mortality rein the offspring of male rodents that were treated with methadone prior to mating. Hinein these studies, the female rodents were not treated with methadone, indicating paternally-mediated developmental toxicity. Specifically, methadone administered to the male rat prior to mating with methadone-naive females resulted rein decreased weight gain hinein progeny after weaning. The male progeny demonstrated reduced thymus weights, whereas the female progeny demonstrated increased adrenal weights. Further, behavioral testing of these male and female progeny revealed significant differences in behavioral tests compared to control animals, suggesting that paternal methadone exposure can produce physiological and behavioral changes in progeny in this model. Other animal studies have reported that perinatal exposure to opioids including methadone alters neuronal development and behavior hinein the offspring. Perinatal methadone exposure rein rats has been linked to alterations rein learning ability, motor activity, thermal regulation, nociceptive responses and sensitivity to drugs.

Under the requirements of this REMS program, the drug manufacturer must develop educational programs regarding the safe and effective use of opioids for your doctor

Keep methadone hydrochloride tablets in a safe place away from children. Accidental use by a child is a medical emergency that can result rein death.

Wenn geklärt ist, in bezug auf es bei einem Patienten zu dem besagten Opioidmissbrauch gekommen ist außerdem welcher Patient selbst bereit liegend ist, umherwandern erläutern nach lassen, kann die weitere Gangart besprochen werden.

Antibiotics, such as rifampin and rifabutin. These drugs can cause methadone to stop working. This could result rein withdrawal symptoms. Your doctor may change your dosage of methadone as needed.

Methadone can also replace another opioid drug that you have an addiction to. This will keep you from experiencing severe withdrawal symptoms.

Patients should be cautioned that alcohol and other CNS depressants may produce an additive CNS depression when taken with this product and should Beryllium avoided.

In most of the cases seen at typical maintenance doses, concomitant medications and/or clinical conditions such as hypokalemia were noted as contributing factors. However, the evidence strongly suggests that methadone possesses the potential for adverse cardiac conduction effects rein some patients.

Laxatives. Taking these drugs together can change your electrolyte levels. This can cause heart rhythm problems.

Rein contrast, methadone tested positive hinein the rein vivo maus dominant lethal assay and the hinein vivo mammalian spermatogonial chromosome aberration test. Additionally, methadone tested positive hinein the E. coli Desoxyribonukleinsäure repair Organismus and Neurospora crassa and mouse lymphoma forward mutation assays.

Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly during the initial Erhaltungstherapie mit Methadontabletten dosing period.

Patients tolerant to other opioids may be incompletely tolerant to methadone. Incomplete cross-tolerance is of particular concern for patients tolerant to other mu-opioid agonists World health organization are being converted to treatment with methadone, thus making determination of dosing during opioid treatment conversion complex. Deaths have been reported during conversion from chronic, high-dose treatment with other opioid agonists. Therefore, it is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (Weiher DOSAGE AND ADMINISTRATION, Table 1, for appropriate conversion schedules).